Time of Flight Secondary Ion Mass Spectrometry imaging for precise localization of zirconium-labelled trastuzumab in xenograft cancer tumour tissues
نویسندگان
چکیده
• A Zirconium labeled drug was visualized in tumors by Imaging Mass Spectrometry. Time of Flight Secondary Ion Spectrometry (ToF-SIMS) used parallel with immunohistochemistry. ToF-SIMS is a quick and sensitive technique to image zirconium labelled biologics. high-precision complement immunoPET using the same established radiotracers. The human epidermal growth factor receptor 2 (HER2) specific radiotracer zirconium-Desferrioxamine(DFO)-trastuzumab ex-vivo imaging ovarian breast cancer xenograft tumor sections. Heterogeneous spatial distribution [ 90 Zr + ] ions reflected heterogeneous localization trastuzumab, observed immunohistochemistry staining HER2 tumors. Our results show that biologics at microscale tissues.
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ژورنال
عنوان ژورنال: Microchemical Journal
سال: 2022
ISSN: ['1095-9149', '0026-265X']
DOI: https://doi.org/10.1016/j.microc.2022.107860